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Tumor 'floor plans' may predict immunotherapy response better than current biomarkers
Spatial transcriptomics is a powerful tool for creating a detailed map of not just how genes are expressed in a piece of tissue, but also where genetic activity takes place in different cells and locations within the tissue.
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Researchers applied spatial transcriptomics to map gene expression within tumor tissues, creating detailed “floor plans” of the tumor microenvironment. Their analysis indicates that these spatial maps may forecast how well patients respond to immunotherapy, potentially outperforming existing biomarkers. The approach highlights the importance of locating genetic activity within tumors to assess treatment outcomes.
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