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Rare cortical neurons can synchronize brain activity and promote sleep in mice

What makes the brain fall asleep? For nearly a century, scientists have looked to structures deep within the brain for the answer.

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A study published Sept. 9 in Nature challenges the view that the cerebral cortex merely follows deep brain sleep signals. Led by Dr. Renata Batista‑Brito of Icahn School of Medicine at Mount Sinai, the research shows that rare cortical neurons can actively synchronize brain activity and promote sleep in mice. This finding suggests the cortex plays a direct role in initiating sleep, expanding the traditional model that attributes sleep control solely to deeper brain structures.

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