Summary

Inside the brains of some cognitively normal adults, firing patterns were able to foretell Alzheimer's disease years before the onset of memory loss or the accumulation of plaques and tangles, according to new Stanford Medicine–led research. For others, different firing patterns indicated the opposite—brains unusually resilient to cognitive decline and on track for "super ager" status. The findings , published Nov. 4 in Science Advances , suggest a new type of early biomarker—perhaps a modifiable one—for cognitive decline in old age.

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