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SMU vs. Louisville prediction, picks, odds, spread: Mustangs, Cardinals meet in top-25 clash
It's not often that one of the biggest conference games of the year is your conference opener, but that's the situation for No. 23 Louisville as it hosts No.
Summary
It's not often that one of the biggest conference games of the year is your conference opener, but that's the situation for No. 23 Louisville as it hosts No. 16 SMU in a top-25 battle that will set the stage for the rest of the ACC title race. SMU and Louisville have each played for the ACC Championship in the last three years and entered the 2026 season as two of the top contenders to challenge Miami for league supremacy.
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