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Rams vs. 49ers prediction, odds, time: 2026 NFL Australia game picks from proven model
NFC West contenders open their regular seasons when the San Francisco 49ers battle the Los Angeles Rams in the 2026 NFL Australia Week 1 matchup in Melbourne on Thursday.
AI Summary
The Los Angeles Rams and San Francisco 49ers will open the 2026 NFL season in the league’s first Australia game, meeting at Melbourne Cricket Ground on Thursday night. Both clubs finished the 2025 season tied for second in the NFC West with 12‑5 records, after each losing to the Seattle Seahawks in the playoffs. Aaron Donald is sidelined for the Rams as he continues conditioning following a two‑year retirement. Kickoff is set for 8:35 p.m. ET (10:35 a.m. local), with the Rams listed as 3.5‑point favorites and the over/under total at 47.5 points.
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