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Toward experiment-guided AlphaFold: Researchers overcome AI tool's single-conformation limitation

The AI-based program AlphaFold predicts a protein's 3D structure with remarkable accuracy.

Source Phys.org AI Summary Updated 1h 50m ago

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The AI-based program AlphaFold predicts a protein's 3D structure with remarkable accuracy. However, it tends to reduce heterogeneous structures to a single dominant conformation, or shape, and overlooks experimental conditions that can alter local structure. Researchers at the Institute of Science and Technology Austria (ISTA) and international collaborator…

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