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Tiny DNA rotor lets microscopes track gene transcription one base pair at a time
Scientists often describe life as a series of chemical reactions. Pallav Kosuri, Ph.D., describes life as movement.
AI Summary
Scientists have engineered a tiny DNA rotor that amplifies the motion of protein‑DNA interactions, enabling microscopes to follow gene transcription at the resolution of a single base pair. The device consists of a corkscrew‑shaped stem that attaches to a protein, an X‑shaped handle, and a fluorescent dye probe that together magnify the underlying molecular movement. Researchers suggest that visualizing these mechanical motions is essential for fully understanding and manipulating molecular function.
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