Science
Reconstructed ancient protein maps how bacterial enzymes evolved distinct functions
How do related proteins develop different functions? This is the question investigated by a research team involving Kiel University, DESY and the Center for Structural Systems Biology (CSSB).
AI Summary
Researchers from Kiel University, DESY, and the Center for Structural Systems Biology reconstructed the common ancestor of two bacterial enzymes. Led by Holger Sondermann, the team produced the long‑extinct protein in the laboratory. The study aimed to understand how related proteins evolve distinct functions. By recreating the ancestral enzyme, the researchers can compare its structure and activity to modern variants, shedding light on functional divergence in bacterial enzymes.
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