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The tumor is surrounded by normal prostate tissue (blue-gray). Li Prostate tumors can rewire amino acid metabolism to override the normal brakes on cholesterol production, a process that may fuel hormone therapy resistance, according to a study by Weill Cornell Medicine investigators. The preclinical study, published in Nature Metabolism , revealed that a compound called propionyl-CoA, produced by the breakdown of the amino acids isoleucine and valine during normal energy metabolism, acts as a signal that switches on cholesterol production.

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