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New CRISPR approach targets gene fusions found in 1 in 5 cancers
Peter Mac scientists have developed a way to precisely target the "unique molecular fingerprint" created when two genes become abnormally fused together, a discovery that could lead to a new way to treat a wide array of cancers. Dr.
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Scientists at Peter Mac have created a method to precisely target the “unique molecular fingerprint” formed when two genes abnormally fuse, a step that could enable new treatments for many cancers. Dr. Mohamad Fareh notes that gene fusions are a frequent trigger for cancer development, arising when DNA breaks inside a cell are incorrectly repaired, joining portions of different genes together. This approach aims to exploit that specific fusion signature for therapeutic intervention.
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