AI Summary

Scientists have developed a new method to map long‑range genetic interactions in rare immune cells, a step that could clarify how disease‑associated variants influence distant genes. The approach addresses a key obstacle: many risk variants act on genes far from their chromosomal location because DNA folds to bring distant regions into contact. Prior studies struggled to capture these long‑distance regulatory links in the scarce immune cell types that are critical to disease. By enabling the detection of such connections, the technique promises to better link genetic risk to the underlying genes and mechanisms that drive disease.

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