Miniaturized bone marrow-on-a-chip tracks human immune cells as they… | HappeningNow.news

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Miniaturized bone marrow-on-a-chip tracks human immune cells as they build lasting antibody defenses

A scientific team has developed a laboratory model that reveals how antibody-producing plasma cells migrate, mature and survive within human bone marrow, a main location of long-lived antibody-producing plasma cells.

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A scientific team has created a laboratory model that visualizes how antibody‑producing plasma cells migrate, mature and survive within human bone marrow, the primary site of long‑lived plasma cells. The system integrates a lymph‑node‑like organoid with a bone‑marrow‑mimicking tissue chip, enabling researchers to watch key developmental stages that have been hard to capture in humans. This combined platform offers a new way to study plasma‑cell dynamics in a controlled, human‑relevant environment.

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