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Microglia caught eating living motor neurons in ALS mice via unexpected immune pathway
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, according to the CDC, currently affects around 35,000 Americans—with 5,000 more diagnosed each year. Risk climbs with age, and treatments only slow progression.
AI Summary
Researchers observed that in mice with amyotrophic lateral sclerosis, microglia—the brain’s resident immune cells—actively engulfed living motor neurons. This phagocytic activity occurred through an immune pathway not previously linked to neuron loss in ALS. The finding highlights a potential new mechanism contributing to the progressive degeneration of motor neurons that underlies the disease’s muscle weakness and paralysis.
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