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Louisville vs. Ole Miss prediction, odds, time: 2026 college football picks, best bets by expert on 22-9 run
Ole Miss opens the post-Lane Kiffin era with its high-powered offense against a defense-first Louisville squad in a featured Week 1 college football matchup.
AI Summary
Ole Miss will open the season against Louisville in a Week 1 college football matchup. The Rebels, led by head coach Pete Golding, will feature a high‑powered offense with quarterback Trinidad Chambliss returning after a sixth‑year eligibility extension. Louisville will play a defense‑first approach.
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