AI Summary

Researchers note that the intestinal epithelium renews completely every three to five days, the fastest turnover in the body, to cope with mechanical stress and exposure to bacteria. They raise the question of whether the extracellular matrix that binds these cells retains a lasting inflammatory imprint despite this rapid cellular turnover. The implication is that gut tissue could preserve an inflammatory “memory” for over a year, even as the lining itself is constantly replaced.

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