AI Summary

Scientists at St. Jude Children’s Research Hospital identified a gene‑regulatory pathway that enables regulatory T cells to keep gut bacteria from provoking harmful immune attacks. Their research, published in Science Advances, shows that these T cells co‑opt the well‑known COMPASS gene‑expression system to suppress inappropriate immune responses, thereby averting lethal inflammation and autoimmunity. The finding clarifies how the immune system distinguishes beneficial intestinal microbiota from harmful microbes, filling a gap in understanding the genetic controls of this balance.

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