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Chargers vs. 49ers prediction, odds, time: NFL Week 2 preseason picks from proven expert for Thursday's game
Cross-state rivals will meet in Week 2 of the 2026 NFL Preseason when the Los Angeles Chargers host the San Francisco 49ers on Thursday.
Story Brief
Cross-state rivals will meet in Week 2 of the 2026 NFL Preseason when the Los Angeles Chargers host the San Francisco 49ers on Thursday. These franchises have met 45 times in preseason history, with San Fran holding the 26-19 edge. Justin Herbert and Brock Purdy sat in Week 1 but are expected to see action on Thursday.
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