Summary

The immune system may recognize a cancer cell and still fail to destroy it. In a recent study, researchers at Hiroshima University and their international collaborators found that hyperactive YAP and TAZ (YAP/TAZ), two cancer-promoting proteins, were associated with genomic instability that may make cancer cells more recognizable to the immune system, while also increasing PD-L2, which helps the cells suppress T-cell attack. That combination could matter for immune checkpoint inhibitor (ICI) therapy , which can block inhibitory signals that restrain T-cell activity.

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