AI Summary

Researchers at Spain’s Centro Nacional de Investigaciones Cardiovasculares Carlos III, working with international collaborators, have identified previously unknown mechanisms that enable blood vessels to grow without VEGF–VEGFR2 signaling, a pathway commonly targeted in anti‑angiogenic cancer therapies. The discovery could clarify why tumors eventually become resistant to treatments that block VEGF signaling. By revealing alternative routes of angiogenesis, the work points to potential new therapeutic targets aimed at improving the effectiveness of anti‑angiogenic drugs and reducing resistance.

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