AI Summary

Scientists have used a crystalline sponge to determine the structures of large beyond‑rule‑of‑5 (bRo5) molecules, which are pharmaceutical compounds that exceed the traditional 500‑Dalton limit yet retain therapeutic activity. The sponge technique allows crystallographic analysis even when only minute amounts of the complex molecules are available. This approach overcomes the difficulty of characterizing bRo5 compounds with conventional methods, providing detailed structural information that can aid drug development.

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