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Newly identified protein pathway helps HIV stay hidden despite treatment
Current HIV medicines are effective at suppressing the virus in the blood. However, HIV can remain "asleep" or dormant inside certain immune cells and in the brain.
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Scientists at the UNC HIV Cure Center discovered that specific human proteins maintain HIV in a dormant state within immune cells and the brain, forming reservoirs that current therapies cannot eliminate. The study identified a protein pathway that keeps the virus “asleep,” explaining why viral suppression in the blood does not cure infection. Researchers suggest that targeting this pathway could help future cure strategies eradicate persistent HIV. The findings were presented by postdoctoral scholar Waqas Ahmed in the lab of Guochun Jiang.
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