Summary

Many people with major depressive disorder get no relief from current treatments. Newer combinations of existing medications might help, researchers report in JAMA Psychiatry . Persistent low mood, a loss of interest in previously enjoyable activities, lack of energy, feelings of worthlessness, poor concentration and appetite, and suicidal thoughts are symptoms of major depression. A significant percentage of adults suffering from it don't get much relief from conventional antidepressant therapies.

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