Summary

The Substance 's ending is a tragic conclusion to a wild body horror comedy, underscoring the film's views about self-worth and self-destruction in the entertainment industry. The film focuses on the titular "Substance," a mysterious serum and medical by which someone can create a younger copy of themselves. This allows them to spend a week in a "perfect" body for every week in their normal form, although there are strict rules about how to maintain the process.

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