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SMU vs. Louisville prediction, picks, odds, spread: Mustangs, Cardinals meet in top-25 clash
It's not often that one of the biggest conference games of the year is your conference opener, but that's the situation for No. 23 Louisville as it hosts No.
AI Summary
No. 23 Louisville will host No. 16 SMU in a top‑25 matchup that also serves as each team’s conference opener, a rarity for a game of this magnitude. Both programs have appeared in the ACC Championship over the past three seasons and entered the 2026 campaign as leading challengers to Miami’s league dominance. The contest will therefore influence the early ACC title race, though neither team is slated to meet Miami in the regular season this year.
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