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Small protein helps amplify cell signals from receptors targeted by many medicines

A small protein known as p11 may play a much broader role in cellular signaling than previously thought.

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Researchers at Karolinska Institutet have identified the small protein p11 as a broad modulator of cellular signaling, showing that it binds to many receptors that are the targets of widely used drugs. Their experiments reveal that p11’s interactions could influence pathways involved in pain, inflammation and depression. The findings, detailed in Science Advances, suggest that manipulating p11 may open new therapeutic avenues for these conditions.

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