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RNA's first letter may shape antiviral alarms, with A outpacing G
Researchers at the International Institute of Molecular and Cell Biology in Warsaw (IIMCB), led by Prof.
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Researchers at the International Institute of Molecular and Cell Biology in Warsaw found that the first nucleotide of an RNA molecule influences the strength of innate immune activation. In experiments reported in *Molecular Cell*, RNAs that begin with adenosine (A) elicited a stronger antiviral response than nearly identical RNAs that start with guanosine (G). The work, led by Prof. Gracjan Michlewski, highlights how a single base at the RNA 5′ end can modulate cellular alarm signals. This insight helps explain why some RNA sequences provoke more robust immune reactions than others.
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