Reversing radiation-activated immune suppression in cancer | HappeningNow.news

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Reversing radiation-activated immune suppression in cancer

Researchers at the University of Chicago have identified a mechanism to make immune cells reprogrammed by radiation therapy attack tumors rather than protect them.

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Researchers at the University of Chicago discovered that radiation therapy triggers the protein TET2 in immune cells within bone marrow. Activation of TET2 removes chemical tags from RNA, which locks these cells into an immune‑suppressing state. By reversing this reprogramming, the immune cells can be redirected to attack tumors instead of protecting them.

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