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Researchers identify strategy to make pediatric bone cancers more vulnerable to immunotherapy
Ewing sarcoma is a rare and debilitating type of bone cancer affecting young adults and children. Despite intensive treatment with chemotherapy, surgery and radiation, many children do not overcome the disease.
AI Summary
Researchers at the UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center are studying ways to make Ewing sarcoma, a rare bone cancer that affects children and young adults, more responsive to immunotherapy. The team, led by pediatric oncologists Ian Davis and Justin Sperlazza, is focusing on chimeric antigen receptor T‑cell (CAR T‑cell) therapy, which trains a patient’s immune system to attack tumor cells. Their goal is to expand treatment options beyond the current intensive chemotherapy, surgery, and radiation regimens that many children do not survive.
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