AI Summary

Researchers at the University of Virginia used two-photon lifetime microscopy to simultaneously measure cellular metabolism and oxygen levels in the cerebral cortex of mice. The study compared Alzheimer’s disease model mice with healthy, wild‑type controls. Findings showed that mitochondria in the disease model were dysfunctional, while altered blood flow and oxygen availability added extra demands on brain tissue. The combined imaging approach highlights how energy production and oxygen use are disrupted together in Alzheimer’s, offering a new way to characterize metabolic changes in the living brain.

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