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One dose of protein-targeting CAR-T cells shrinks solid tumors in preclinical tests
CAR-T cell therapies have fundamentally transformed the treatment of several blood and lymph node cancers. However, their use in solid tumors such as liver, breast or lung cancer has so far been significantly more difficult.
AI Summary
CAR‑T cell therapies have changed treatment for many blood cancers, but applying them to solid tumors like liver, breast, or lung cancer has been harder. The difficulty stems partly from the lack of suitable target structures on solid‑tumor cells. Immunotherapies usually aim at tumor‑specific features that also drive growth, but such mutations are not always present or usable in solid cancers.
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