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Ole Miss vs. Louisville prediction, picks, odds, spread: Rebels open season against upset-minded Cardinals
The only game on the Week 1 schedule featuring two teams ranked in the preseason AP Top 25 pits No. 9 Ole Miss and No. 24 Louisville for a Sunday night showdown at Nissan Stadium in Nashville.
AI Summary
The Week 1 matchup between No. 9 Ole Miss and No. 24 Louisville will be the only preseason AP Top 25 game on the schedule. It takes place Sunday night at Nissan Stadium in Nashville. Both programs are looking to start their seasons strong while facing tough schedules—Louisville has 11 Power Four opponents, and Ole Miss will begin the SEC’s first nine‑game conference slate. The game is expected to be a high‑scoring affair, with both teams carrying significant offensive expectations.
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