AI Summary

A new chemical reaction has been developed that operates under mild conditions compatible with DNA, allowing it to modify molecules without damaging the attached DNA barcodes. This advancement addresses a key limitation in constructing DNA‑encoded libraries, where traditional reactions can degrade the DNA and restrict the diversity of compounds that can be screened. By preserving DNA integrity, the reaction expands the range of chemical structures that can be incorporated into these libraries, potentially broadening the pool of candidates examined in drug discovery efforts.

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