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NFL Week 1 Australia game prediction, odds, time: 49ers vs. Rams picks by expert on 19-5 run
NFC West rivals and Super Bowl contenders clash when the San Francisco 49ers battle the Los Angeles Rams in a season-opening matchup at Melbourne, Australia, on Thursday.
AI Summary
The San Francisco 49ers will open the 2026 NFL season against the Los Angeles Rams in a Thursday night game at Melbourne’s Cricket Ground in Australia. The Rams enter the matchup as a 3.5‑point favorite, with the over/under set at 48.5 points. Both teams are tied for second in the NFC West after a 12‑5 record in 2025 and are seeking their first Super Bowl appearance in several seasons. Micah Roberts provides expert picks for the game.
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