Summary

A research team has identified the transcription factor C/EBPγ as a novel regulator that simultaneously promotes epithelial-mesenchymal transition (EMT) and DNA double-strand break repair in lung adenocarcinoma cells. The findings, published in Cell Death Discovery , provide new insights into how cancer cells acquire aggressive features and resistance to anticancer treatments. EMT is a reversible cellular program in which epithelial cancer cells acquire mesenchymal characteristics, enhancing their mobility, invasiveness and adaptability. This process is closely associated with tumor progression, metastasis and resistance to therapy.

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