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Missing DNA replication step revealed in first image of pre-initiation complex
Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick has recorded the missing step.
Summary
Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick has recorded the missing step. During cell division, DNA must be copied only once to keep chromosomes physically stable as they are replicated and passed to the next generation. Cells have evolved safety measures to stop DNA replication from going awry, essential to avoiding cancer.
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