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Managing misfolded proteins to prevent Parkinson's disease
The protein alpha-synuclein is abundant in healthy brains and plays an important role in enabling communication between nerve cells.
AI Summary
Alpha‑synuclein normally supports neuronal communication, but when it misfolds it can aggregate into toxic clumps called Lewy bodies, a hallmark of Parkinson’s disease and certain dementias. Recent research shows these misfolded proteins are not confined to a single neuron; they travel through the brain’s fluid spaces and spread from cell to cell. This propagation helps explain how pathological protein accumulation expands across brain regions, contributing to disease progression.
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