Science
LISA to the rescue: Using light to fix cell division
Cell division is a complex process. At the heart of this complexity is a membraneless organelle called the centrosome, which is made up of more than 200 components.
AI Summary
Researchers at the Department of Microbiology and Cell Biology, Indian Institute of Science, have created Light‑Induced Spindle Activation (LISA), a method that can reversibly trigger Aurora A kinase, a crucial centrosomal enzyme for assembling mitotic spindles. The centrosome, a membraneless organelle composed of more than 200 components, clusters these spindle structures to separate genetic material during cell division. LISA enables precise control of spindle formation by activating the kinase with light, addressing long‑standing uncertainty about which centrosome parts are essential for spindle assembly.
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