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How one RNA nucleotide switch activates fluorescent dyes
RhoBAST is a tiny RNA molecule that activates fluorescent dyes, enabling researchers to track RNA molecules in living cells with super-resolution.
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RhoBAST is a tiny RNA molecule that can activate fluorescent dyes, allowing researchers to track RNA molecules inside living cells with super‑resolution imaging. An international collaboration that includes Ronald Micura and his team at the Institute of Organic Chemistry has demonstrated that a small, local “nucleotide flip” within the RNA strand is responsible for triggering the fluorescence. The finding pinpoints the precise structural change that governs dye activation, offering a clearer mechanism for RNA‑based imaging tools.
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