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Genome analysis uncovers candidate genes for hereditary breast and ovarian cancer
Breast cancer is the most common form of cancer among women in Germany: Around 1 in 8 women will develop it during their lifetime. In around 5% to 10% of cases, the condition is caused by a hereditary predisposition.
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A study led by Dr. Doris Steinemann of Hannover Medical School and Dr. Monika Golas of the University of Augsburg has identified additional genes and gene variants that increase the risk of breast cancer. The research expands on the 13 genes currently used for genetic testing, such as BRCA1 and BRCA2, which account for 5% to 10% of hereditary breast cancer cases in Germany. The lead author, Dr. Bernardus Aldrige Allister, was formerly with the MHH Institute of Human Genetics. The findings suggest new targets for genetic screening and risk assessment in women who may develop breast cancer during their lifetime.
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