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Genetic mapping reveals complex traits draw more heritability from intergenic DNA

Schizophrenia, height, cholesterol. Each has its own genetic signature.

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Schizophrenia, height, and blood cholesterol each have distinct genetic signatures composed of DNA variants that differ between individuals. Some traits, like cholesterol levels, are influenced by a relatively small number of variants. Others, such as schizophrenia, involve many thousands of variants, each contributing a very small effect. This extensive involvement of numerous variants is referred to by geneticists as polygenicity.

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