AI Summary

A study led by King’s College London shows that chemotherapy draws stem‑like T cells toward tumors, but macrophages surrounding tumor blood vessels act as a barrier that limits their entry. The researchers identified the enzyme heme oxygenase‑1 (HO‑1) in these macrophages as a key factor maintaining this barrier. Blocking HO‑1 reduced the obstruction, enabling more stem‑like T cells to infiltrate the tumor and boost the antitumor immune response. The findings were published in Cell Stem Cell.

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