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Fast-spreading malaria parasite mutations in Uganda may weaken Africa's most widely used malaria therapy
Researchers searching for genetic clues to the growing problem of malaria drug resistance have identified new mutations associated with the parasite's decreased susceptibility to current treatment.
AI Summary
Researchers sequenced whole genomes of malaria parasites from hundreds of Ugandan patients and identified a cluster of genetic variants that markedly reduce susceptibility to the drugs most commonly used to treat malaria in Africa and the United States. The study, led by Brown University scientists, found these mutations spreading rapidly, suggesting they confer a survival advantage to the parasite.
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