AI Summary

The Regenerative Medicine Project has created human induced pluripotent stem cells with doubled chromosomes, called tetraploid iPS cells, by fusing cells. These tetraploid cells were then differentiated into cardiomyocytes. The resulting heart cells mimic the natural chromosome doubling that occurs during cardiomyocyte maturation in the body. The researchers report that this chromosome duplication enhances cardiac function, producing cells with stronger, faster contractions. The work demonstrates a new method for improving the performance of stem‑cell‑derived heart cells.

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