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CRISPR safety check evaluates intended and unintended mutations
A team of researchers led by Professor Akitsu Hotta (Department of Clinical Application) developed a comprehensive framework that combines computational prediction, experimental validation and whole-genome analysis to evaluate intended…
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A new framework for evaluating the safety of CRISPR-Cas9 gene editing has been developed by a team of researchers. This framework combines computational prediction, experimental validation, and whole-genome analysis to assess both intended and unintended mutations caused by CRISPR-Cas9 delivered via lipid nanoparticles. The development provides a practical strategy to improve the safety of genome-editing therapies, which could have implications for their widespread adoption.
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