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Common deworming drug helps restore lung cancer's sensitivity to targeted therapy in mice
A form of lung cancer, which is found in about 10%–15% of Western patients and 40%–50% of Asian patients, is driven by a mutation in the epidermal growth factor receptor (EGFR) gene.
Summary
A form of lung cancer, which is found in about 10%–15% of Western patients and 40%–50% of Asian patients, is driven by a mutation in the epidermal growth factor receptor (EGFR) gene. Gefitinib is a go-to drug that shuts down this protein's signals. However, over time, cancer cells develop resistance to the drug and keep dividing even while treatment is underway, rendering gefitinib powerless. A recent study published in PLOS One has found a way out of this resistance trap.
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