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Commanders vs. 49ers prediction, odds, time: 'Monday Night Football' picks by proven model
The San Francisco 49ers will look to stay perfect on the year when they take on the Washington Commanders in a key NFC matchup on 'Monday Night Football.
Summary
The San Francisco 49ers will look to stay perfect on the year when they take on the Washington Commanders in a key NFC matchup on 'Monday Night Football.' San Francisco defeated Seattle 32-29 in Week 5, while Washington tied the New York Giants 27-27. The Commanders (1-3-1), who are fourth in the NFC East, are 0-2 on the road this season. The 49ers (5-0), who have outscored their opponents 154-93, are 3-0 on their home field in 2026.
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