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College football odds, picks, predictions for Week 4, 2026: Computer likes Colorado, USC
The Week 4 college football schedule is when conference play officially kicks off for many teams. The Big Ten features the likes of USC vs.
AI Summary
Week 4 marks the start of conference play for many college football teams, with several key matchups highlighted. The Big Ten slate includes USC hosting Oregon as a 3‑point favorite and Michigan traveling to Iowa as a 5.5‑point underdog. In the SEC, Texas visits Tennessee with a 4.5‑point spread favoring Tennessee, while the Big 12 pits Colorado against Baylor, giving Colorado a 10‑point advantage. Additional games such as Notre Dame’s matchup are also noted for the week’s betting picks.
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