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College football odds, picks, predictions for Week 1, 2026: Computer backs Auburn, Cincinnati
SportsLine's model has revealed its 2026 Week 1 college football picks for LSU vs. Clemson, Ole Miss vs.
Story Brief
While the 2026 college football season got a hearty appetizer with Week 0, the main course will be served with the Week 1 college football schedule. There are 90 games involving FBS teams on the slate, with several intriguing non-conference matchups. Lane Kiffin makes his LSU debut versus Clemson on Saturday, which has his Tigers as 10.5-point favorites per the latest Week 1 college football odds.
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