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Clemson vs. LSU prediction, odds, time: 2026 Week 1 college football picks by expert who went 90-68
SportsLine expert Eric Cohen has revealed his best bets for Clemson Tigers vs. LSU Tigers as Lane Kiffin makes his LSU debut in Week 1
Summary
Lane Kiffin makes his LSU head coaching debut as the 11th-ranked Tigers battle the Clemson Tigers in a Week 1 college football matchup on Saturday. Clemson, who tied for seventh in the ACC at 4-4, were 7-6 overall in 2025. LSU, meanwhile, was 10th in the SEC and 7-6 overall last season. LSU leads the all-time series 4-1, including a 17-10 win last year.
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