Health
CAR-T cells enhanced with navigation system to penetrate lymph nodes more efficiently
Chimeric antigen receptor T-cell therapy, or CAR-T, has transformed treatment for blood cancers. The immunotherapy involves reprogramming a patient's own immune cells to recognize and attack tumor cells.
AI Summary
Researchers at the Max Delbrück Center engineered CAR‑T cells to express the CCR7 receptor, enabling the cells to migrate more efficiently into lymph nodes. The modification improved the cells’ ability to reach and kill lymphoma cells located in the lymphatic system. The study, led by Dr. Uta Höpken and Dr. Maria Zschummel, was published in *Cancer Immunology Research*.
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